Sometimes the appropriate response to reality is to go insane.
Don't try to solve serious matters in the middle of the night.
It is sometimes an appropriate response to reality to go insane.
Reality is whatever refuses to go away when I stop believing in it.
Reality is that which, when you stop believing in it, doesn't go away.
Perhaps if you know you are insane then you are not insane. Or you are becoming sane, finally. Waking up.
This, to me, is the ultimately heroic trait of ordinary people; they say no to the tyrant and they calmly take the consequences of this resistance.
Drug misuse is not a disease, it is a decision, like the decision to step out in front of a moving car. You would call that not a disease but an error of judgment.
The basic tool for the manipulation of reality is the manipulation of words. If you can control the meaning of words, you can control the people who must use the words.
Science fiction writers, I am sorry to say, really do not know anything. We can't talk about science, because our knowledge of it is limited and unofficial, and usually our fiction is dreadful.